Compound name
LAROPIPRANT
Protein family
GPCR
Target name
PTGDR
Affinity biochemical (nM)
0.58
Affinity on-target cellular (nM)
0.6
Compound EUbOPEN ID
EUB0000459a
SMILES
CS(=O)(=O)C1=C2N(CC3=CC=C(Cl)C=C3)C3=C(CC[C@@H]3CC(O)=O)C2=CC(F)=C1
InChIKey
NXFFJDQHYLNEJK-CYBMUJFWSA-N
NCBI gene ID
5729
UniProt ID
Q13258
Synonyms
DP, DP1, PTGDR1
Mode of action
Antagonist
Affinity biochemical definition
Ki
Affinity biochemical assay type
Binding affinity to human DP receptor expressed in HEK293 cells
Affinity Biochemical Source Knowledge
17300164
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Activity at human DP receptor in washed platelets assessed as inhibition of PGD2-induced cAMP accumulation
Affinity on-target cellular relation
=