Compound name
ELAGOLIX
Protein family
GPCR
Target name
GNRHR
Affinity biochemical (nM)
0.89
Affinity on-target cellular (nM)
1.51
Compound EUbOPEN ID
EUB0000472aNa
SMILES
O=C(N(CC1=C(F)C=CC=C1C(F)(F)F)C(C)=C2C3=C(F)C(OC)=CC=C3)N(C[C@H](NCCCC([O-])=O)C4=CC=CC=C4)C2=O.[Na+]
InChIKey
DQYGXRQUFSRDCH-UQIIZPHYSA-M
NCBI gene ID
2798
UniProt ID
P30968
Synonyms
LHRHR
Mode of action
Antagonist
Affinity biochemical definition
Ki
Affinity biochemical assay type
Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting
Affinity Biochemical Source Knowledge
19006286
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate production
Affinity on-target cellular relation
=