Compound name
CARIPRAZINE
Protein family
GPCR
Target name
DRD3
Affinity biochemical (nM)
0.09
Affinity on-target cellular (nM)
5.75
Compound EUbOPEN ID
EUB0000493aCl
SMILES
[H]Cl.CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1
InChIKey
GPPJWWMREQHLQT-BHQIMSFRSA-N
NCBI gene ID
1814
UniProt ID
P35462
Mode of action
Antagonist
Affinity biochemical definition
Ki
Affinity biochemical assay type
Binding affinity to human dopamine D3 receptor
Affinity Biochemical Source Knowledge
22537450
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding assay
Affinity on-target cellular relation
=