Compound name
Meclizine dihydrochloride
Protein family
NR
Target name
NR1I3
Affinity on-target cellular (nM)
63
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000551aCl
SMILES
CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
InChIKey
VCTHNOIYJIXQLV-UHFFFAOYSA-N
NCBI gene ID
9970
UniProt ID
Q14994
Synonyms
MB67, CAR1, CAR
Mode of action
Antagonist
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1210/me.2004-0046
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for VDR, NR1I2, UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037