Compound name
GW0742
Protein family
NR
Target name
PPARD
Affinity on-target cellular (nM)
1
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000569a
SMILES
CC1=C(C=CC(=C1)SCC2=C(N=C(S2)C3=CC(=C(C=C3)C(F)(F)F)F)C)OCC(=O)O
InChIKey
HWVNEWGKWRGSRK-UHFFFAOYSA-N
NCBI gene ID
5467
UniProt ID
Q03181
Synonyms
NUC1, NUCII, FAAR, NR1C2
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1016/s0960-894x(03)00207-5
https://doi.org/10.1021/jm300068n
https://doi.org/10.1016/j.bmcl.2018.03.010
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(PPARA) = 14.79, fold-activation(PPARG) = 10.47, inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
2