Compound name
GW3965
Protein family
NR
Target name
NR1H2
Affinity on-target cellular (nM)
2100
CG-Set
NR
Recommended Concentration
3 µM
Compound EUbOPEN ID
EUB0000572aCl
SMILES
C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl
InChIKey
NMPUWJFHNOUNQU-UHFFFAOYSA-N
NCBI gene ID
7376
UniProt ID
P55055
Synonyms
NER, NER-I, RIP15, LXR-b, LXRb
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
fold-activation(NR2C1) = 1.98, fold-activation(NR2E1) = 1.82, inactive at 3 µM for UL48, RXRA, HNF4A, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
2