Compound name
Sobetirome
Protein family
NR
Target name
THRB
Affinity on-target cellular (nM)
7
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000585a
SMILES
CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCC(=O)O
InChIKey
QNAZTOHXCZPOSA-UHFFFAOYSA-N
NCBI gene ID
7068
UniProt ID
P10828
Synonyms
THRB1, THRB2, NR1A2, THR1, ERBA-BETA, GRTH
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm0201013
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037