Compound name
GW 2580
Protein family
Protein Kinase
Target name
CSF1R
Affinity biochemical (nM)
60
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000598a
SMILES
NC1=NC(N)=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=N1
InChIKey
MYQAUKPBNJWPIE-UHFFFAOYSA-N
NCBI gene ID
1436
UniProt ID
P07333
Synonyms
C-FMS, CSFR, CD115
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1073/pnas.0502000102
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Closest targets with Kd <100 nM: NTRK2, targets with 100 nM < Kd < 1 µM: NTRK1, NTRK3, others >1 µM
Selectivity Source Knowledge
https://lincs.hms.harvard.edu/db/sm/10401-101/
Selectivity Number of Off-targets
3