Compound name
GSK461364
Protein family
Protein Kinase
Target name
PLK1
Affinity biochemical (nM)
0.5
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000603a
SMILES
CN1CCN(CC1)CC2=CC3=C(C=C2)N=CN3C4=CC(O[C@H](C)C5=C(C(F)(F)F)C=CC=C5)=C(S4)C(N)=O
InChIKey
ZHJGWYRLJUCMRT-QGZVFWFLSA-N
NCBI gene ID
5347
UniProt ID
P53350
Mode of action
Inhibitor
Affinity biochemical definition
Ki
Affinity biochemical assay type
Enzymatic Z'-LITE assay (Invitrogen)
Affinity Biochemical Source Knowledge
https://doi.org/10.1158/0008-5472.CAN-09-0945
Affinity biochemical relation
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Selectivity platform
Kinase Profiler (Millipore)
Selectivity platform number of targets
262
Selectivity remarks
Screened at 10 µM, closest targets as % inhibition: PDGFRA(V561D) (96%), RPS6KA6 (92%), RPS6KA3(92%), PKN2(92%), RPS6KA1(91%), PIM1 (90%); Screened against 48 kinases (GlaxoSmithKline panel), closest target: IC50(NEK2) = 158 nM;
Selectivity Source Knowledge
https://doi.org/10.1158/0008-5472.CAN-09-0945
Selectivity Number of Off-targets
6