EUB0000608a_PLK1

Chemical structure of compound EUB0000608a
Compound name
Mps1-IN-2
Protein family
Protein Kinase
Target name
PLK1
Affinity biochemical (nM)
61
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000608a
SMILES
OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(CCN4C5CCCC5)=O)C4=N3)C=C2)CC1
InChIKey
WELBJLUKWAJOQV-UHFFFAOYSA-N
NCBI gene ID
5347
UniProt ID
P53350
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Ambit Competition binding assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/nchembio.345
Affinity biochemical relation
=
Selectivity platform
Ambit kinase binding assay panel
Selectivity platform number of targets
352
Selectivity remarks
Screened at 10 µM, closest targets as % of contr.: PLK1(4.3%); In vitro follow up of closest targets: IC50(GAK) = 140 nM, IC50(PLK1/3/4) = 61/ 1600/ 3100 nM, IC50(STK33) = 5000 nM
Selectivity Source Knowledge
https://doi.org/10.1038/nchembio.345
Selectivity Number of Off-targets
1