Compound name
Mps1-IN-2
Protein family
Protein Kinase
Target name
TTK
Affinity biochemical (nM)
12
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000608a
SMILES
OC1CCN(C2=CC(OCC)=C(NC3=NC=C(N(C)C(CCN4C5CCCC5)=O)C4=N3)C=C2)CC1
InChIKey
WELBJLUKWAJOQV-UHFFFAOYSA-N
NCBI gene ID
7272
UniProt ID
P33981
Synonyms
MPS1, MPS1L1, CT96, MPH1
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Ambit Competition binding assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/nchembio.345
Affinity biochemical relation
=
Selectivity platform
Ambit kinase binding assay panel
Selectivity platform number of targets
352
Selectivity remarks
Screened at 10 µM, closest targets as % of contr.: PLK1(4.3%); In vitro follow up of closest targets: IC50(GAK) = 140 nM, IC50(PLK1/3/4) = 61/ 1600/ 3100 nM, IC50(STK33) = 5000 nM
Selectivity Source Knowledge
https://doi.org/10.1038/nchembio.345
Selectivity Number of Off-targets
1