Compound name
CX-4945
Protein family
Protein Kinase
Target name
CSNK2A1
Affinity biochemical (nM)
1
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000613a
SMILES
OC(C1=CC2=NC(NC3=CC(Cl)=CC=C3)=C(C=CN=C4)C4=C2C=C1)=O
InChIKey
MUOKSQABCJCOPU-UHFFFAOYSA-N
NCBI gene ID
1457
UniProt ID
P68400
Synonyms
Cka1, Cka2
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric activity assay (15 µM ATP)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm101251q
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Millipore)
Selectivity platform number of targets
238
Selectivity remarks
Screened at 0.5 µM, closest targets: IC50(DAPK3) = 17 nM, IC50(FLT3) = 35 nM, IC50(TBK1) = 35 nM, IC50(CLK3) = 41 nM, IC50(HIPK3) = 45 nM, IC50(PIM1) = 46 nM, IC50(CDK1/cyclinB) = 56 nM (radiometric filter-binding assay, conc. ATP = Km); Follow-up in cellular assays: IC50(FLT3/ PIM1/ CDK1) >10 µM;
Selectivity Source Knowledge
https://doi.org/10.1021/jm101251q
Selectivity Number of Off-targets
7