Compound name
AIM 100
Protein family
Protein Kinase
Target name
TNK2
Affinity biochemical (nM)
21.58
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000620a
SMILES
C1(NC[C@H]2OCCC2)=C(C(C3=CC=CC=C3)=C(C4=CC=CC=C4)O5)C5=NC=N1
InChIKey
XNFHHOXCDUAYSR-SFHVURJKSA-N
NCBI gene ID
10188
UniProt ID
Q07912
Synonyms
p21cdc42Hs, ACK, ACK1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric enzyme assay (HotSpot assay, Reaction Biology)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/22566699/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, closest targets with dTm >5K: dTm(STK6) = 8.23K, dTm(STK10) = 7.64 K, dTm(PLK4) = 5.33 K, further targets dTm 3-5K: dTm(BMX) = 4.14 K, dTm(ULK3) = 4.13 K, dTm(SLK) = 3.82 K, dTm(AURKB) = 3.81 K, dTm(ABL1) = 3.52 K; HotSpot assay (Reaction Biology), 30 targets, in-vitro potencies of closest targets: IC50(ABL1) = 705.9 nM, IC50(BTK) = 871.7 nM, IC50(LCK) = 432.3 nM, IC50(LYN) = 346.7 nM, https://pubmed.ncbi.nlm.nih.gov/22566699/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/22566699/