Compound name
GSK2578215A
Protein family
Protein Kinase
Target name
LRRK2
Affinity biochemical (nM)
10.9
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000622a
SMILES
O=C(C1=C(OCC2=CC=CC=C2)C=CC(C3=CC(F)=NC=C3)=C1)NC4=CC=CN=C4
InChIKey
WCIGMFCFPXZRMQ-UHFFFAOYSA-N
NCBI gene ID
120892
UniProt ID
Q5S007
Synonyms
ROCO2, DKFZp434H2111, FLJ45829, RIPK7
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
HTRF assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1016/j.bmcl.2012.06.104
Affinity biochemical relation
=
Selectivity platform
KinomScan Ambit
Selectivity platform number of targets
329
Selectivity remarks
Screened at 10 µM, Ambit score <10 at 10 µM, off-targets with PoC <50%
Selectivity Source Knowledge
https://doi.org/10.1016/j.bmcl.2012.06.104
Selectivity Number of Off-targets
3