Compound name
GNE-9605
Protein family
Protein Kinase
Target name
LRRK2
Affinity biochemical (nM)
2
Affinity on-target cellular (nM)
19
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000629a
SMILES
CNC1=C(C(F)(F)F)C=NC(NC2=C(Cl)N([C@H]3CCN(C4COC4)C[C@@H]3F)N=C2)=N1
InChIKey
PUXPEQJKNAWNQA-AAEUAGOBSA-N
NCBI gene ID
120892
UniProt ID
Q5S007
Synonyms
ROCO2, DKFZp434H2111, FLJ45829, RIPK7
Mode of action
Inhibitor
Affinity biochemical definition
Ki
Affinity biochemical assay type
Biochemical assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm401654j
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular assay (LRRK2 phosphorylation)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (Invitrogen)
Selectivity platform number of targets
178
Selectivity remarks
Screened at 0.1 µM, closest targets with PoC <50%, TAK1-TAB1
Selectivity Source Knowledge
https://doi.org/10.1021/jm401654j
Selectivity Number of Off-targets
1