Compound name
GSK872
Protein family
Protein Kinase
Target name
RIPK3
Affinity biochemical (nM)
1.3
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000632a
SMILES
CC(C)S(C1=CC(C(NC2=CC=C(SC=N3)C3=C2)=CC=N4)=C4C=C1)(=O)=O
InChIKey
ZCDBTQNFAPKACC-UHFFFAOYSA-N
NCBI gene ID
11035
UniProt ID
Q9Y572
Synonyms
RIP3
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
ADP-Glo assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1016/j.molcel.2014.10.021
Affinity biochemical relation
=
Selectivity platform
HotSpot assay platform (Reaction Biology)
Selectivity platform number of targets
300
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: ABL (12%), BRK (13%), FYN (18%), KDR (17%)
Selectivity Source Knowledge
https://doi.org/10.1016/j.molcel.2014.10.021
Selectivity Number of Off-targets
0