Compound name
BAY 12-17389
Protein family
Protein Kinase
Target name
TTK
Affinity biochemical (nM)
0.63
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000634a
SMILES
CC1=C(C=CC(=C1)C2=CN=C3N2N=C(C=C3NCCC(F)(F)F)OC4=C(C(=C(C=C4)OC)F)F)C(=O)NC5CC5
InChIKey
WNEILUNVMHVMPH-UHFFFAOYSA-N
NCBI gene ID
7272
UniProt ID
P33981
Synonyms
MPS1, MPS1L1, CT96, MPH1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
TR-FRET-based in vitro kinase assays
Affinity Biochemical Source Knowledge
https://doi.org/10.1158/1535-7163.MCT-15-0500
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
395
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: JNK2(4%), KIT(2%), PDGFRB(0%)
Selectivity Source Knowledge
https://doi.org/10.1158/1535-7163.MCT-15-0500
Selectivity Number of Off-targets
3