Compound name
CCT245737
Protein family
Protein Kinase
Target name
CHEK1
Affinity biochemical (nM)
1.3
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000636a
SMILES
FC(F)(F)C(C=N1)=C(NC[C@@H]2OCCNC2)C=C1NC3=CN=C(C#N)C=N3
InChIKey
YBYYWUUUGCNAHQ-LLVKDONJSA-N
NCBI gene ID
1111
UniProt ID
O14757
Synonyms
CHK1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Microfluid assay (CALIPER)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.5b01938
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Dundee)
Selectivity platform number of targets
124
Selectivity remarks
Screened at 10 µM, closest targets: IC50(MAPK15) = 130 nM, IC50(RPS6KA3) = 361 nM, IC50(RPS6KA2) = 362 nM; IC50(FLT3) = 582 nM, IC50(NUAK1) = 711 nM, IC50(CLK2) = 1370 nM (Z’-Lyte assay)
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.5b01938
Selectivity Number of Off-targets
6