Compound name
AKT inhibitor VIII
Protein family
Protein Kinase
Target name
AKT2
Affinity biochemical (nM)
210
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000653a
SMILES
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=C(N=C6C=C7C(=NC=N7)C=C6N5)C8=CC=CC=C8
InChIKey
IWCQHVUQEFDRIW-UHFFFAOYSA-N
NCBI gene ID
208
UniProt ID
P31751
Synonyms
PKBb
Mode of action
Allosteric Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Kinase inhibition assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/15664853/
Affinity biochemical relation
=
Selectivity platform
KINOMEscan (DiscoverX; including mutants)
Selectivity platform number of targets
456
Selectivity remarks
Screened at 10 µM, closest target as % of contr.: PIK3CB (6.7%)
Selectivity Source Knowledge
https://lincs.hms.harvard.edu/db/datasets/20083/results?sort=percentControl
Selectivity Number of Off-targets
1