Compound name
PI-103
Protein family
Protein Kinase
Target name
PIK3C2B
Affinity biochemical (nM)
43
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000658a
SMILES
Oc1cccc(c1)c1nc(N2CCOCC2)c2oc3ncccc3c2n1
InChIKey
TUVCWJQQGGETHL-UHFFFAOYSA-N
NCBI gene ID
5287
UniProt ID
O00750
Synonyms
C2-PI3K
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Scintillation proximity radiometric assay (1 µM ATP)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/17575152/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (competition-binding assays)
Selectivity platform number of targets
442
Selectivity remarks
In-vitro potencies of closest targets in the screen: Kd(MTOR) = 12 nM, Kd(HIPK3) = 310 nM, Kd(PIP5K2C) = 620 nM, Kd(RIOK2), Kd(DAPK3) = 840 nM, Kd(YSK4) = 930 nM, full screening data are available as supporting information;
Screened against 69 kinases at 1 µM, closest targets as % of control: SmMLCK (62%), HIPK2 (67%), full screening data available in paper, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267365/;
Screened against 69 kinases at 1 µM, closest targets as % of control: SmMLCK (62%), HIPK2 (67%), full screening data available in paper, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267365/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/22037378/
Selectivity Number of Off-targets
6