Compound name
PD0325901
Protein family
Protein Kinase
Target name
MAP2K1
Affinity biochemical (nM)
82
Affinity on-target cellular (nM)
0.33
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000666a
SMILES
FC1=C(F)C(NC2=CC=C(I)C=C2F)=C(C(NOC[C@H](O)CO)=O)C=C1
InChIKey
SUDAHWBOROXANE-SECBINFHSA-N
NCBI gene ID
5604
UniProt ID
Q02750
Synonyms
MEK1, MAPKK1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.9b01528
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Whole cell assay (murine colon 26 (C26) carcinoma cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
451
Selectivity remarks
Screened at 10 µM, none target within 10-fold, closest target as % of contr.: PIK3CA (I800L, 33%)
Selectivity Source Knowledge
http://identifiers.org/lincs.data/LDS-1066
Selectivity Number of Off-targets
0