Compound name
Volasertib
Protein family
Protein Kinase
Target name
PLK1
Affinity biochemical (nM)
0.87
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000669a
SMILES
CC[C@@H]1C(N(C)C2=CN=C(NC3=C(OC)C=C(C(N[C@@H]4CC[C@@H](N5CCN(CC6CC6)CC5)CC4)=O)C=C3)N=C2N1C(C)C)=O
InChIKey
SXNJFOWDRLKDSF-STROYTFGSA-N
NCBI gene ID
5347
UniProt ID
P53350
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay (7.5 µM ATP)
Affinity Biochemical Source Knowledge
https://doi.org/10.1158/1078-0432.CCR-08-2445
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
255
Selectivity remarks
Kinases screened in Kinobeads assay,closest target: Kd(CAMKK2) = 195 nM; Kd (BRD4) = 79 nM.
Selectivity Source Knowledge
https://doi.org/10.1126/science.aan4368
Selectivity Number of Off-targets
0