Compound name
Volasertib
Protein family
Protein Kinase
Target name
PLK2
Affinity biochemical (nM)
5
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000669a
SMILES
CC[C@@H]1C(N(C)C2=CN=C(NC3=C(OC)C=C(C(N[C@@H]4CC[C@@H](N5CCN(CC6CC6)CC5)CC4)=O)C=C3)N=C2N1C(C)C)=O
InChIKey
SXNJFOWDRLKDSF-STROYTFGSA-N
NCBI gene ID
10769
UniProt ID
Q9NYY3
Synonyms
SNK
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay (7.5 µM ATP)
Affinity Biochemical Source Knowledge
https://doi.org/10.1158/1078-0432.CCR-08-2445
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
255
Selectivity remarks
Kinases screened in Kinobeads assay,closest target: Kd(CAMKK2) = 195 nM; Kd (BRD4) = 79 nM.
Selectivity Source Knowledge
https://doi.org/10.1126/science.aan4368
Selectivity Number of Off-targets
0