Compound name
GSK1070916
Protein family
Protein Kinase
Target name
AURKB
Affinity biochemical (nM)
5
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000674a
SMILES
CN(C)CC1=CC=CC(C2=CC3=C(C4=CN(CC)N=C4C5=CC=C(NC(N(C)C)=O)C=C5)C=CN=C3N2)=C1
InChIKey
QTBWCSQGBMPECM-UHFFFAOYSA-N
NCBI gene ID
9212
UniProt ID
Q96GD4
Synonyms
Aik2, IPL1, AurB, AIM-1, ARK2, STK5, PPP1R48
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic activity assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm901870q
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
328
Selectivity remarks
In vitro activity of closest targets:IC50(FLT1/4) = 42/74 nM, IC50(TIE2) = 59 nM, IC50(SIK) = 70 nM, IC50(FGFR1) = 78 nM
Selectivity Source Knowledge
https://doi.org/10.1158/1535-7163.MCT-09-0041
Selectivity Number of Off-targets
5