Compound name
NMS-1286937
Protein family
Protein Kinase
Target name
PLK1
Affinity biochemical (nM)
2
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000677a
SMILES
CN1CCN(C2=CC=C(OC(F)(F)F)C(NC3=NC=C(CCC4=C5N(CCO)N=C4C(N)=O)C5=N3)=C2)CC1
InChIKey
QHLVBNKYJGBCQJ-UHFFFAOYSA-N
NCBI gene ID
5347
UniProt ID
P53350
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1016/j.bmcl.2011.03.054
Affinity biochemical relation
=
Selectivity platform
Kinase Profiler (Millipore)
Selectivity platform number of targets
296
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: CDK9 (10%), FLT3(D835Y) (9%), PLK1 (3%); Screened additionally against 58 kinases (radiometric kinase assay), closesttargets: IC50(FLT3) = 510 nM, IC50(MELK) = 744 nM, IC50(CK2) = 826 nM, other targets IC50 >10 µM (PMID: 21470862)
Selectivity Source Knowledge
https://doi.org/10.1158/1535-7163.MCT-11-0765
Selectivity Number of Off-targets
3