Compound name
Cobimetinib
Protein family
Protein Kinase
Target name
MAP2K1
Affinity biochemical (nM)
4.2
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000684a
SMILES
FC1=C(NC2=CC=C(I)C=C2F)C(C(N3CC([C@@H]4CCCCN4)(O)C3)=O)=CC=C1F
InChIKey
BSMCAPRUBJMWDF-KRWDZBQOSA-N
NCBI gene ID
5604
UniProt ID
Q02750
Synonyms
MEK1, MAPKK1
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1158/0008-5472.CAN-11-1515
Affinity biochemical relation
=
Selectivity platform
Kinase panel, literature
Selectivity platform number of targets
259
Selectivity remarks
In vitro inhibition (biochemical potency): >100 fold selective for MEK, other targets >10µM
Selectivity Source Knowledge
https://doi.org/10.1126/science.aan4368
Selectivity Number of Off-targets
0