Compound name
Ribociclib
Protein family
Protein Kinase
Target name
CDK6
Affinity biochemical (nM)
39
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000686a
SMILES
O=C(N(C)C)C(N1C2CCCC2)=CC(C1=N3)=CN=C3NC(C=C4)=NC=C4N5CCNCC5
InChIKey
RHXHGRAEPCAFML-UHFFFAOYSA-N
NCBI gene ID
1021
UniProt ID
Q00534
Synonyms
PLSTIRE
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic activity assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/s41523-019-0121-y
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest target with PoC <10%: ABL2 (5.8%)
Selectivity Source Knowledge
https://lincs.hms.harvard.edu/db/datasets/20330/
Selectivity Number of Off-targets
1