Compound name
Alpelisib
Protein family
Protein Kinase
Target name
PIK3CA
Affinity biochemical (nM)
5
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000689a
SMILES
CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F
InChIKey
STUWGJZDJHPWGZ-LBPRGKRZSA-N
NCBI gene ID
5290
UniProt ID
P42336
Synonyms
PI3K
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay (Kinase-Glo® assay)
Affinity Biochemical Source Knowledge
https://doi.org/10.1016/j.bmcl.2013.05.007
Affinity biochemical relation
=
Selectivity platform
Kinase panel (literature + Ambit panel + Invitrogen panel)
Selectivity platform number of targets
442
Selectivity remarks
Screened at 10 µM, > 50-fold selective
Selectivity Source Knowledge
https://doi.org/10.1016/j.bmcl.2013.05.007
Selectivity Number of Off-targets
0