Compound name
Omipalisib
Protein family
Protein Kinase
Target name
PIK3CA
Affinity biochemical (nM)
0.019
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000691a
SMILES
COC1=C(NS(C2=CC=C(F)C=C2F)(=O)=O)C=C(C3=CC(C(C4=CC=NN=C4)=CC=N5)=C5C=C3)C=N1
InChIKey
CGBJSGAELGCMKE-UHFFFAOYSA-N
NCBI gene ID
5290
UniProt ID
P42336
Synonyms
PI3K
Mode of action
Inhibitor
Affinity biochemical definition
Ki
Affinity biochemical assay type
HTRF-based inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/ml900028r
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
442
Selectivity remarks
Screened at 10 µM, closest targets with < 10% of contr.: GAK, JAK1, STK16, TTK, PIK3C2G, MAP2K4; Screened against 240 kinases (Milipore panel): >10000-fold selective
Selectivity Source Knowledge
https://lincs.hms.harvard.edu/db/datasets/20084/
https://doi.org/10.1021/ml900028r
Selectivity Number of Off-targets
6