Compound name
Umbralisib
Protein family
Protein Kinase
Target name
PIK3CD
Affinity biochemical (nM)
14
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000696a
SMILES
C[C@@H](C1=C(C2=CC(F)=CC=C2)C(C3=CC(F)=CC=C3O1)=O)N4N=C(C5=CC=C(OC(C)C)C(F)=C5)C6=C(N)N=CN=C46
InChIKey
IUVCFHHAEHNCFT-INIZCTEOSA-N
NCBI gene ID
5293
UniProt ID
O00329
Synonyms
p110D
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.8b01298
Affinity biochemical relation
=
Selectivity platform
Radioisotope filter binding assay (Reaction Biology)
Selectivity platform number of targets
359
Selectivity remarks
Screened at 1 µM, closest target as % of contr.: CSNK1E (39%)
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.8b01298
https://patents.google.com/patent/WO2017079558A1/en
Selectivity Number of Off-targets
1