Compound name
SR-302
Protein family
Protein Kinase
Target name
MAPK11
Affinity biochemical (nM)
45.1
Affinity on-target cellular (nM)
196
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000712a
SMILES
CS(N1CCCC(NC([C@@H](NC(C2=CC=C(C=C2)CNC(C3=CN=C4C=CC=CN34)=O)=O)CCC5CCCCC5)=O)C1)(=O)=O
InChIKey
WGMNFJAFXXXRLZ-GEVKEYJPSA-N
NCBI gene ID
5600
UniProt ID
Q15759
Synonyms
p38-2, p38Beta, SAPK2
Mode of action
Inhibitor
Negative control
SR301
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzyme kinetic assay (Reaction Biology)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.1c00868
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/SR-302
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: ABL1-nonphosphorylated (14%), RIPK2 (30%), RPS6KA5RPS6KA5(Kin.Dom.2-C-terminal) (35%), CHEK2 (37%), PIK3CA (37%), STK38L (40%); Follow-up IC50s in cellular NanoBRET assays: all targets IC50 >25 µM (>125-fold selective);
Selectivity Source Knowledge
https://doi.org/10.1021/acs.jmedchem.1c00868
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/SR-302
Selectivity Number of Off-targets
0