Compound name
MRL-SYKi
Protein family
Protein Kinase
Target name
SYK
Affinity biochemical (nM)
0.9
Affinity on-target cellular (nM)
38
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000714a
SMILES
OC([C@H](C(C)(C)C1)CC[C@]1(O)C2=NC=C(S2)C3=CC(NC4=CC=CC(C(F)(F)F)=N4)=C(C)C=C3)=O
InChIKey
HUOXIXBCBFNFKF-VOIUYBSRSA-N
NCBI gene ID
6850
UniProt ID
P43405
Mode of action
Inhibitor
Negative control
MRL-SYKi-NC
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/MRL-SYKi
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular human mast cell degranulation assay
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (Invitrogen)
Selectivity platform number of targets
265
Selectivity remarks
Screened at 1 µM, no targets within 10-fold, closest kinases IC50 >100-fold
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/MRL-SYKi
Selectivity Number of Off-targets
0