Compound name
L-Skepinone
Protein family
Protein Kinase
Target name
MAPK11
Affinity on-target cellular (nM)
40.2
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000717a
SMILES
C1Cc2cc(ccc2C(c2cc(ccc12)OC[C@@H](CO)O)=O)Nc1ccc(cc1F)F
InChIKey
HXMGCTFLLWPVFM-GOSISDBHSA-N
NCBI gene ID
5600
UniProt ID
Q15759
Synonyms
p38-2, p38Beta, SAPK2
Mode of action
Inhibitor
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KINOMEscan (DiscoverX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, >1000-fold selective, off-targets with PoC <50%
Selectivity Source Knowledge
https://doi.org/10.1038/nchembio.761
Selectivity Number of Off-targets
0