Compound name
L-Skepinone
Protein family
Protein Kinase
Target name
MAPK14
Affinity biochemical (nM)
5
Affinity on-target cellular (nM)
13.6
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000717a
SMILES
C1Cc2cc(ccc2C(c2cc(ccc12)OC[C@@H](CO)O)=O)Nc1ccc(cc1F)F
InChIKey
HXMGCTFLLWPVFM-GOSISDBHSA-N
NCBI gene ID
1432
UniProt ID
Q16539
Synonyms
PRKM14, p38, Mxi2, PRKM15
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
ELISA (cell free)
Affinity Biochemical Source Knowledge
https://doi.org/10.1038/nchembio.761
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KINOMEscan (DiscoverX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, >1000-fold selective, off-targets with PoC <50%
Selectivity Source Knowledge
https://doi.org/10.1038/nchembio.761
Selectivity Number of Off-targets
0