Compound name
FS-694
Protein family
Protein Kinase
Target name
MAPK14
Affinity biochemical (nM)
0.2
Affinity on-target cellular (nM)
14.9
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000718a
SMILES
C1Cc2cc(ccc2C(c2cc(ccc12)C(NCCN1CCOCC1)=O)=O)Nc1ccc(c(c1)NC(c1ccccc1)=O)F
InChIKey
JWZSSEWMVYKYKW-UHFFFAOYSA-N
NCBI gene ID
1432
UniProt ID
Q16539
Synonyms
PRKM14, p38, Mxi2, PRKM15
Mode of action
Inhibitor
Negative control
FM-743
Affinity biochemical definition
IC50
Affinity biochemical assay type
ELISA (cell free)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/acs.jmedchem.7b00745
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
441
Selectivity remarks
Screened at 1 µM off-targets with PoC <35%
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/FS-694
Selectivity Number of Off-targets
5