Compound name
TP_030_1
Protein family
Protein Kinase
Target name
RIPK1
Affinity biochemical (nM)
3.9
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000719a
SMILES
CN1C([C@@H](N2CCC3=CN(N=C3C2=O)CC4=CC=CC=C4)COC5=C1C=CC=C5)=O
InChIKey
MAHFVAHPQSLLJF-IBGZPJMESA-N
NCBI gene ID
8737
UniProt ID
Q13546
Synonyms
RIP
Mode of action
Allosteric inhibitor
Negative control
TP_030_n
Affinity biochemical definition
Ki
Affinity biochemical assay type
TR-FRET binding assay (Invitrogen)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-1
https://doi.org/10.1021/acs.jmedchem.7b01647
Affinity biochemical relation
=
Selectivity platform
Takeda global kinase panel
Selectivity platform number of targets
303
Selectivity remarks
Highly selective; screen against 45 GPCR targets, closest target: Ki(GABA/PBR) = 374.92 nM; clean in Eurofins-Panlabs radioligand binding assay, screen against 68 targets, at 10 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/TP-030-1
Selectivity Number of Off-targets
0