Compound name
BAY-678
Protein family
Protease
Target name
ELANE
Affinity biochemical (nM)
20
CG-Set
Protease set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000735a
SMILES
CC1=C(C(C)=O)[C@@H](c2ccc(C#N)nc2)NC(N1c1cccc(c1)C(F)(F)F)=O
InChIKey
PGIVGIFOWOVINL-GOSISDBHSA-N
NCBI gene ID
1991
UniProt ID
P08246
Synonyms
ELANE, ELA2
Mode of action
Inhibitor
Negative control
BAY-677
Affinity biochemical definition
IC50
Affinity biochemical assay type
Microtiter-based biochemical assay
Affinity Biochemical Source Knowledge
https://doi.org/10.1002/cmdc.201500131
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-678
Affinity biochemical relation
=
Selectivity platform
Serine protease panel, literature
Selectivity platform number of targets
21
Selectivity remarks
> 30-fold selective over 21 serine proteases (for all IC50 > 30 µM); Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest targets as % of contr.: RPS6KA4 (33.5%), PRKG1 (45.5%), PRKACB (48.7%); Screened against 45 GPCR targets (PSDP screen) at 10 µM, closest target: Ki(HRH3) = 3.07 µM, Ki(DTR1A) = 4.98 µM, Ki(ADRB1) = 5.45 µM; Radioligand binding assays (Lead Profiling Screen, Eurofins) against 64 receptors and transporters at 10 µM: > 30-fold selective
Selectivity Source Knowledge
https://doi.org/10.1002/cmdc.201500131
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-678
Selectivity Number of Off-targets
0