Compound name
BI-665915
Protein family
PPi transporter
Target name
ALOX5AP
Affinity biochemical (nM)
1.7
CG-Set
Other targets
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0000749a
SMILES
C[C@@](C1CC1)(c1ccc(cc1)c1cnc(N)nc1)c1nc(c2cnn(CC(N(C)C)=O)c2)on1
InChIKey
QGPXEIMWTKWHMH-DEOSSOPVSA-N
NCBI gene ID
241
UniProt ID
P20292
Synonyms
ALOX5AP, FLAP
Mode of action
Inhibitor
Negative control
BI-0153
Affinity biochemical definition
IC50
Affinity biochemical assay type
Binding assay (measuring radio-labeled ligand [125I]-L-691831(PE NEX084) displacement)
Affinity Biochemical Source Knowledge
https://doi.org/10.1021/jm501185j
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI%20665915
Affinity biochemical relation
=
Selectivity remarks
No closely related mammalian protein known; Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest targets as % of contr.: ABL1(Q252H)-nonphosphorylated (0%), GRK7 (0%), CHUK (0%), PK5 (0%), JAK1 (33%), PRKCE (44%); Screened against 546 targets (Invitrogen kinase panel) at 3 µM: all kinases showed < 30% inhibition; Screened against 68 targets (Eurofins-Panlabs panel) at 10 µM: clean profile; Screened against 137 targets in CEREP screen at 20 µM, closest targets as % inhibition: FLT1 (64%), ABL1 (67%); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest target as % of inhibition: SLC6A3 (61%);
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI%20665915