Compound name
GSM1
Protein family
Protease
Target name
PSEN1@Protease
CG-Set
Protease set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000753a
SMILES
Cc1ncn(c2ccc(c3cn([C@@H]4C(N(c5cccc(F)c5CC4)CC(F)(F)F)=O)nn3)cc2OC)c1
InChIKey
AAHNBILIYONQLX-QFIPXVFZSA-N
NCBI gene ID
5663
UniProt ID
P49768
Synonyms
ACNINV3, AD3, FAD, PS-1, PS1, S182
Mode of action
Allosteric modulator
Negative control
GSM-NC
Selectivity platform
Enzyme and Receptor panel (MSD Pharma/Taiwan)
Selectivity platform number of targets
165
Selectivity remarks
No near family aspartyl proteases, closest targets: IC50(SLC6A4) = 13 nM, IC50(SLC6A3) = 536 nM, IC50(Na channel site 2) = 1000 nM; Screened against 468 kinases (KinomeScan DiscoverX) at 1 µM, closest targets as % of contr.: ACVR2A (0%), EGFR (0%), MAP4K4 (0%), MAP4K5 (5.8%); Screened against 45 GPCR targets (PDSP screen) at 10 µM, closest targets: Ki(SLC6A4) = 24 nM, Ki(SLC6A3) = 191 nM, Ki(SLC6A2) = 808 nM;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/GSM1
Selectivity Number of Off-targets
0