Compound name
AC-261066
Protein family
NR
Target name
RARA
Affinity on-target cellular (nM)
630
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0000835a
SMILES
CCCCOCCOC1=C(SC(=N1)C2=CC(=C(C=C2)C(=O)O)F)C
InChIKey
GPLGAQQQNWMVMM-MYAJQUOBSA-N
NCBI gene ID
5914
UniProt ID
P10276
Synonyms
RAR, NR1B1
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm050891r
https://doi.org/10.1021/jm801532e
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
rel. activation(RXRA)=19.35% to bexarotene, inactive at 1 µM for UL48, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037
Selectivity Number of Off-targets
1