Compound name
BIBO3304
Protein family
GPCR
Target name
NPY1R
Affinity on-target cellular (nM)
0.69
CG-Set
GPCR set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001000bAD
SMILES
N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1.O=C(O)C(F)(F)F
InChIKey
TVMJSGGZULFVCZ-XMMPIXPASA-N
NCBI gene ID
4886
UniProt ID
P25929
Mode of action
Antagonist
Negative control
BIBO3457
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Radioligand binding assay (human Y1 receptor stably expressed in baby hamster kidney (BHK) cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/9806339/
Affinity on-target cellular relation
=
Selectivity platform
Eurofins-Panlabs
Selectivity platform number of targets
102
Selectivity remarks
Screened at 10 µM against a panel of GPCRs, kinases, and other enzymes, closest target as % of control: M1 (73%), full screening data available on OpenMe website, https://www.opnme.com/molecules/npy1r-bibo3304;
Screened at 10 µM against 44 GPCRs, hydrolases, and ion channels (SafetyScreen44™), closest targets as % of control: KAPPA(KOP, 30%), V1A (29%), full screening data available on OpenMe website, https://www.opnme.com/molecules/npy1r-bibo3304;
Screened at 10 µM against 44 GPCRs, hydrolases, and ion channels (SafetyScreen44™), closest targets as % of control: KAPPA(KOP, 30%), V1A (29%), full screening data available on OpenMe website, https://www.opnme.com/molecules/npy1r-bibo3304;
Selectivity Source Knowledge
https://www.opnme.com/molecules/npy1r-bibo3304