EUB0001024a_DYRK1B

Chemical structure of compound EUB0001024a
Compound name
Lorecivivint
Protein family
Protein Kinase
Target name
DYRK1B
Affinity biochemical (nM)
41.2
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001024a
SMILES
CC(C)CC(=O)Nc1cncc(-c2ccc3[nH]nc(-c4nc5cncc(-c6cccc(F)c6)c5[nH]4)c3c2)c1
InChIKey
AQDWDWAYVBQMAM-UHFFFAOYSA-N
NCBI gene ID
9149
UniProt ID
Q9Y463
Synonyms
MIRK
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic inhibition assay (Thermo Fisher)
Affinity Biochemical Source Knowledge
https://www.sciencedirect.com/science/article/pii/S106345841930994X?via%3Dihub
Affinity biochemical relation
=
Selectivity platform
Thermo Fisher Invitrogen Z-lyte and Lantha based platform
Selectivity platform number of targets
318
Selectivity remarks
Screened at 500 nM, >90% inhibiton; in-vitro potency (Enzymatic inhibition assay, Thermo Fisher) of closest target: IC50(CLK1) = 239 nM, IC50(HIPK3) = 126 nM, https://www.sciencedirect.com/science/article/pii/S106345841930994X?via%3Dihub;
Selectivity Source Knowledge
https://www.sciencedirect.com/science/article/pii/S106345841930994X?via%3Dihub
Selectivity Number of Off-targets
2