1. Chemogenomics
  2. Chemogenomic set
  3. EUB0001060a_DDR2

EUB0001060a_DDR2

Chemical structure of compound EUB0001060a
Compound name
SR301
Protein family
Protein Kinase
Target name
DDR2
Affinity on-target cellular (nM)
15500
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001060a
SMILES
CS(N1CCCC(NC([C@@H](NC(C2=CC=C(CNC3=NC=NC4=C3[N][N]N4C5=CC=CC=C5)C=C2)=O)CCC6CCCCC6)=O)C1)(=O)=O
InChIKey
JINDDPNTLQVRRX-ACEFPKFPSA-N
NCBI gene ID
4921
UniProt ID
Q16832
Synonyms
TKT
Mode of action
Negative control for SR-302
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/34506142/
Affinity on-target cellular relation
0
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 100 nM, closest targets as % of control: STK38L (24%), SRPK2 (34%), PIK3CA (44%), TNIK(45%), LRRK2(51%), NEK1(51%), RIOK1(54%), EIF2AK2 (55%), FYN (56%), STK32A (57%), RIPK2 (59%), FRK (60%), NIM1K (60%), PRPF4B (60%)
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/34506142/
Selectivity Number of Off-targets
0