Compound name
BI-3017
Protein family
Hydrolase
Target name
ENPP2
Affinity biochemical (nM)
8900
CG-Set
Other targets
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001066a
SMILES
CC1=NC(COC(N2C[C@H]3[C@H](CNC(C4=CC5=C(C=C4)NN=N5)=O)[C@H]3C2)=O)=CC=N1
InChIKey
ZDITZGRCUFFQRS-PHZGNYQRSA-N
NCBI gene ID
5168
UniProt ID
Q13822
Synonyms
ENPP2, ATX, PDNP2
Mode of action
Negative control for BI-2545
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical assay (LPA measurement)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-2545
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of contr.: PIM2 (0%), VRK2 (29%), KIT(V55D,V654A) (41%), NLK (41%); Screened at 10 µM against 45 GPCRs (PDPS screen), closest targets as % of inhibition: HTR1E (31.76%), HTR2C (31.08%), ADRA1B (30.19%);
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BI-2545