Compound name
FM-743
Protein family
Protein Kinase
Target name
MAPK11
Affinity on-target cellular (nM)
16200
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001068a
SMILES
O=C(C1=CC=CC=C1)N(C)C1=C(F)C=CC(N(C)C2C=CC(=C(C=2)CC2)C(C(=C23)C=C(C(NCCN2CCOCC2)=O)C=C3)=O)=C1
InChIKey
RHXKLUBQGQKHCH-UHFFFAOYSA-N
NCBI gene ID
5600
UniProt ID
Q15759
Synonyms
p38-2, p38Beta, SAPK2
Mode of action
Negative control for FS-694 and L-Skepinone
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/FS-694
Affinity on-target cellular relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 1 µM, closest targets as % of control: NEK1(45%), STK38L (47%), BMX(50%)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/FS-694