Compound name
Resmetirom
Protein family
NR
Target name
THRB
Affinity on-target cellular (nM)
200
CG-Set
NR
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001081a
SMILES
CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
InChIKey
FDBYIYFVSAHJLY-UHFFFAOYSA-N
NCBI gene ID
7068
UniProt ID
P10828
Synonyms
THRB1, THRB2, NR1A2, THR1, ERBA-BETA, GRTH
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://doi.org/10.1021/jm4019299
Affinity on-target cellular relation
=
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 10 µM for UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037