Compound name
BAY-069
Target name
BCAT2
Affinity biochemical (nM)
130
Affinity on-target cellular (nM)
874
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001109a
SMILES
Cc1ccccc1Oc1cc(c2ccccc2c1[Cl])N1C(C=C(C(F)(F)F)NC1=O)=O
InChIKey
UNSHMXUHOHBLIQ-UHFFFAOYSA-N
NCBI gene ID
587
UniProt ID
O15382
Synonyms
BCAT2, BCATM, BCT2, ECA40
Mode of action
Inhibitor
Negative control
BAY-771
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-069
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular mechanistic assay (BCAA measurement in MDA-MB-231, high BCAT2 expressing cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-069
Affinity on-target cellular relation
0
Selectivity platform
Safety screen (Eurofins)
Selectivity platform number of targets
77
Selectivity remarks
Clean selectivity profile with no target activity >50%; Screened in enzymatic assays against other transaminases: IC50(GOT1/2) >50 µM; Screened at 6 µM against 30 proteases, all targets IC50 >10 µM; Screened at 2 µM against 45 kinases (enzymatic assays), clean selectivity profile with all kinases IC50 >7 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-069
Selectivity Number of Off-targets
0