Compound name
BAY-3153
Protein family
GPCR
Target name
CCR1
Affinity on-target cellular (nM)
3
CG-Set
GPCR set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001121a
SMILES
CCOc1cc(ccc1[Cl])N1C2CN(CC1COC2)C([C@H]1C[C@@H](CN1c1ccc(cc1)[Cl])O)=O
InChIKey
LZSPYTNDRPEZBK-OXYJHPMESA-N
NCBI gene ID
1230
UniProt ID
P32246
Synonyms
CKR-1, MIP1aR, CD191
Mode of action
Antagonist
Negative control
BAY-173
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
CCR1 cellular Ca2+-flux assay (using calcium-optimized stable cell line #HTS005C)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-3153
Affinity on-target cellular relation
0
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, in-vitro potencies of closest targets: Ki(TMEM97) = 1476.05 nM, Ki(SIGMAR1) = 1828.52 nM, Ki(GABA/PBR) = 1805.52 nM, Ki(OPRK1) = 3005.38 nM; Screened in enzymatic assays against other CCR family members: inactive on hCCR3, IC50(hCCR2) >30 µM, IC50(hCCR4) >30 µM, IC50(hCCR%) >30 µM, IC50(hCCR6) >30 µM, IC50(hCCR7) >30 µM, IC50(hCCR8) >30 µM, IC50(hCCR9) >30 µM, IC50(hCCR10) >30 µM, IC50(hCXCR1) >30 µM, IC50(hCXCR2) >30 µM, IC50(hCXCR3) >30 µM, IC50(hCXCR4) >30 µM, IC50(hCXCR5) >30 µM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-3153
Selectivity Number of Off-targets
0