Compound name
Homer
Target name
WDR5
Affinity biochemical (nM)
18
Affinity on-target cellular (nM)
53
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001122a
SMILES
CC1=C(C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(CCCCNC(C4=CC=C(C5=CC=C(N6CCN(C)CC6)C(NC(C7=CNC(C=C7C(F)(F)F)=O)=O)=C5)C=C4)=O)=O)=O)=O)C=C2)SC=N1
InChIKey
OFNZESNEBSQKSE-BQGOKDIQSA-N
NCBI gene ID
11091
UniProt ID
P61964
Synonyms
SWD3, CFAP89
Mode of action
PROTAC, degrader
Negative control
nc_WDR5 and nc_VHL
Affinity biochemical definition
Kd
Affinity biochemical assay type
ITC
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00146
Affinity biochemical relation
0
Affinity on-target cellular definition
DC50
Affinity on-target cellular assay type
HiBit assay (WDR5 degradation in MV4-11 cells)
Affinity on-target cellular source knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00146
Affinity on-target cellular relation
0
Selectivity platform
Proteomics
Selectivity remarks
Screened at 1 µM in quantitative proteomic studies, clean selectivty profile
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00146