Compound name
UNC6934
Protein family
Methyltransferase
Target name
NSD2 (PWWP1 domain)
Affinity biochemical (nM)
91
Affinity on-target cellular (nM)
1230
CG-Set
Epigenetic set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001126a
SMILES
O=C(C1=CC=C(CN(C2CC2)C(C3=CC4=C(NC(CO4)=O)C=C3)=O)C=C1)NC5=CC=NC=N5
InChIKey
KOZGEDUWAQFVAV-UHFFFAOYSA-N
Mode of action
Antagonist
Negative control
UNC7145
Affinity biochemical definition
Kd
Affinity biochemical assay type
SPR measurement
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/34782742/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET PPI assay (at 1 µM)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/UNC6934
Affinity on-target cellular relation
=
Selectivity remarks
DSF screen: Selective for NSD2-PWWP1 over 15 other human PWWP domains; clean panel of 33 methyltransferase domains, including the H3K36 methyltransferases NSD1, NSD2, NSD3 and SETD2;
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/UNC6934